Increased asymmetric dimethylarginine levels in severe transient tachypnea of the newborn

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Isik D., Bas A. Y., Demirel N., Kavurt S., Aydemir O., Kavurt A., ...Daha Fazla

Journal of Perinatology, cilt.36, sa.6, ss.459-462, 2016 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 36 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1038/jp.2016.9
  • Dergi Adı: Journal of Perinatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.459-462
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır

Özet

© 2016 Nature America, Inc.Objective : Nitric oxide (NO) is synthesized by NO synthase (NOS), and asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. We aimed to investigate l-arginine and ADMA levels in transient tachypnea of the newborn (TTN) and their relationship with systolic pulmonary artery pressure (PAP) and disease severity. Study Design : Infants born at ≥35 weeks gestational age with clinical signs and chest X-ray findings consistent with TTN were enrolled; controls were recruited at the same time. l-arginine and ADMA levels were measured at 12 to 24 h (first samples) and at 48 to 72 h (second samples). Systolic PAP was evaluated on the second day. Patients were divided according to the duration of tachypnea and designated as group A (duration ≤72 h) and group B (duration >72 h).Results:In the first samples, the ADMA levels were significantly higher in patients with TTN compared with controls (P<0.001). In the second samples, the ADMA levels were significantly higher in group B compared with that in group A (P=0.019). In group A patients, the second ADMA levels were significantly lower compared with that in the first samples (P<0.001), whereas the second ADMA levels remained unchanged compared with the first samples in group B. Systolic PAP values were significantly higher in group B compared with that in group A patients (P=0.033). Conclusion : Increased ADMA concentration may reduce NO synthesis, leading to increased PAP and thus longer duration of tachypnea.