Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels.

Oztas E., Ozler S., Ersoy E., Ersoy A. O., Tokmak A., Ergin M., ...Daha Fazla

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, cilt.29, sa.9, ss.1515-9, 2016 (SCI-Expanded, Scopus)

Özet

Objective: The main aim of this study was to investigate the first trimester maternal serum secreted frizzle-related protein-5 (Sfrp-5) levels and to evaluate the predictive value on the subsequently developed gestational diabetes mellitus (GDM).Methods: A total of 40 pregnant women who subsequently developed GDM and 44 age- and pre-pregnancy BMI-matched healthy pregnant women were enrolled in this prospective case-control study. First trimester serum Sfrp-5 levels were evaluated to determine if there is an association with the onset of GDM, by using logistic regression analysis.Results: Decreased first trimester serum Sfrp-5 levels (OR=14.332, 95%CI: 4.166-49.301, p<0.001) were found to be significantly associated with the increased risk of GDM. There were no statistically significant differences in serum Sfrp-5 levels between the diet- and insulin-treated GDM groups and also serum Sfrp-5 levels were not found to be predictive for adverse perinatal outcomes (p>0.05).Conclusions: Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of GDM.