© 2015 by the authors.Increasing attention has been given to energy utilization in Turkey. In this report, we present an energy efficiency evaluation and economic feasibility analysis of a geothermal heating and cooling system (GSHP) and a mechanical compression water chiller system (ACHP) to improve the energy utilization efficiency and reduce the primary energy demand for industrial use. Analyses of a mechanical water chiller unit, GSW 180, and geothermal heating and cooling system, EAR 431 SK, were conducted in experimental working areas of the office buildings in a cigarette factory in Mersin, Turkey. The heating and cooling loads of the cigarette factory building were calculated, and actual thermal data were collected and analyzed. To calculate these loads, the cooling load temperature difference method was used. It was concluded that the geothermal heating and cooling system was more useful and productive and provides substantial economic benefits.