Does the platelet-to-lymphocyte ratio have a prognostic effect in patients with myelodysplastic syndrome?
Bratislava Medical Journal, cilt.121, sa.6, ss.422-427, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 121 Sayı: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.4149/bll_2020_068
- Dergi Adı: Bratislava Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
- Sayfa Sayıları: ss.422-427
- Anahtar Kelimeler: Acute leukemia, Cellular differentiation, Chronic cytopenia, Hematologic abnormalities, Marrow biopsy, Myelodysplastic syndromes, Thrombocytopenia
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
INTRODUCTION: Myelodysplastic syndromes (MDS) include various hematologic abnormalities characterized by chronic cytopenia due to disruption in cellular differentiation. This study aims to evaluate the prognostic value of PLR in patients with MDS. MATERIAL AND METHODS: Clinical-laboratory fi ndings and the results of bone marrow biopsies of MDS patients before treatment were recorded. p value of <0.05 was considered statistically signifi cant. SPSS version 20.0 was used for statistical analysis. RESULTS: The study included 62 patients with median follow-up time of 62.8±4.5 months and median age of 68.5 years. In 13 patients, acute leukemia was transformed. In these subjects, a PLR cut-off level of 46 was established for mortality (p=0.015). We found a signifi cant relationship between PLR and multilineage series with the presence of dysplasia (p=0.017). The survival analysis showed a decreased survival in cases with dysplasia in two and/or more series, transformation into acute leukemia, and thrombocytopenia. CONCLUSION: Our study demonstrated that there was a relationship between PLR and MDS with multilineage dysplasia (mld-MDS). PLR is investigated as an infl ammatory fi nding in various hematologic malignancies. Further studies investigating the value of PLR in MDS are needed to determine whether PLR may be a marker of bone marrow dysplasia grading (Tab. 2, Fig. 4, Ref. 32). Text in PDF www.elis.sk.