©Copyright 2021 by Gazi University Medical Faculty - Available on-line at web site http://medicaljournal.gazi.edu.tr/Objective: We aimed to evaluate the role of high sensitivity-CRP (hs-CRP), procalcitonin (PCT), and neopterin in the diagnosis of chronic low-grade inflammation in obesity according to waist-hip ratio and body mass index. Materials and Methods: 67 obese, overweight, and healthy adults were included with a mean age of 41.1±10 years. All participants were divided into two groups according to the waist-hip ratio (WHR<0.9 group A, WHR≥ 0.9 group B) and into three groups according to body mass index (BMI) (BMI< 25kg/m2 - group 1, BMI-25-29.9 kg/m2 - group 2, BMI≥ 30 kg/m2 – group 3). Hs-CRP, PCT, neopterin levels of the groups were compared. Lipid profile and blood glucose levels were also evaluated. Results: There was no significant difference in Hs-CRP, neopterin, PCT between the groups based on the waist-hip ratio (p>0.05). In BMI groups, Hs-CRP levels were related to the degree of obesity, and the differences between group 1 and group 3, and group 2 and group 3 were significant (p<0.05). There was no difference in neopterin levels among the groups (p> 0.05). In the PCT levels, there were statistical significance between group1 and group3 and between group 2 and group 3, but no difference was found between group 1 and group 2 (p>0.05). Conclusion: It was shown that the increase in total fat mass in the body may lead to an increase in inflammation markers. However, it was concluded that this difference is more closely related to the degree of obesity rather than fat distribution.