Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis


SÖNMEZ M. G. , Kozanhan B., Deniz C. D. , Iyisoy M. S. , Kilinc M. T. , Ecer G., ...More

INVESTIGATIVE AND CLINICAL UROLOGY, vol.60, no.4, pp.258-266, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.4111/icu.2019.60.4.258
  • Title of Journal : INVESTIGATIVE AND CLINICAL UROLOGY
  • Page Numbers: pp.258-266

Abstract

Purpose: A dynamic thiol/disulfide balance is pivotal in organizing anti-oxidant defense, detoxification, apoptosis, and enzyme activities, as well as transcription and cellular signal-transfer mechanisms. The connection between urolithiasis and oxidant/antioxidant status, which can be assessed through thiol-disulfide homeostasis (TDH), has not yet been examined. In this study, we evaluated the effects of TDH on the formation, size, and location of stones by examining the associations between TDH parameters and urolithiasis.