Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients


Kutluhan M. A. , Taş A., Şahin A., Ürkmez A., Topaktas R., Ataç Ö., ...Daha Fazla

International Journal of Clinical Practice, cilt.74, sa.12, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 74 Konu: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1111/ijcp.13636
  • Dergi Adı: International Journal of Clinical Practice

Özet

© 2020 John Wiley & Sons LtdBackground: The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in Covid-19 disease. Objective: In this retrospective study, we analysed the clinical features of patients diagnosed with Covid-19 and investigated the effect of Covid-19 on kidney function. Methods: Ninety-six patients diagnosed with Covid-19 were included in our study. Demographic features (Age, gender, co-morbidities), symptoms, thorax CT findings, Covid-19 PCR results and laboratory findings were recorded. The clinical features of the patients were analysed and kidney function values before Covid-19 diagnosis were compared with kidney function values after Covid-19 diagnosis. Results: Most presenting symptom was fever (51%). Most accompanying co-morbidity was hypertension (56%). According to laboratory findings; ferritin, D-dimer and C-reactive protein levels were statistically significantly higher in ARDS group than severe pneumonia and pneumonia group (P =.002, P =.001 and P <.001, respectively). Also lymphocyte levels were statistically significantly lower in ARDS group than severe pneumonia and pneumonia group (P =.042). According to KDIGO criteria 3 (3.1%) patients had AKI during the hospital stay. For all patients, there was statistically significant difference between basal, 1st, 5th and 10th day BUN and SCr levels (P =.024 and P =.018, respectively). For severe pneumonia group there was statistically significant difference between basal, 1st, 5th and 10th day SCr levels (P =.045). Conclusion: Our study demonstrated that Covid-19 can cause renal impairment both with pneumonia and ARDS. A large-scale prospective randomised studies are needed to reach final judgement about this topic.