The predictive value of ischemia-modified albumin in the diagnosis of acute appendicitis: A prospective case–control study Akut apandisit tanısında iskemi modifiye albüminin prediktif değeri: İleriye yönelik olgu kontrol çalışması

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Ünsal A., Turhan V. B., Ozturk D., Bulus H., TÜRKEŞ G. F., EREL Ö.

Ulusal Travma ve Acil Cerrahi Dergisi, cilt.28, sa.4, ss.523-528, 2022 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.14744/tjtes.2020.58675
  • Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.523-528
  • Anahtar Kelimeler: Appendicitis, ischemia-modified albumin, predictive value
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

BACKGROUND: Surgical planning is critical for ongoing treatment and prognosis of the disease’s course after an appendicitis diag-nosis. Ischemia-modified albumin (IMA) has been used as a biomarker for a variety of ischemia-related disorders in the past. The aim of this study is to determine the IMA level in patients with AA and to evaluate its predictive significance. METHODS: A total of 139 participants were enrolled in the trial. After diagnosis and before surgery, the amount of plasma IMA was tested. Patients diagnosed with appendicitis in Group 1 (n=97) and volunteer surgical patients not diagnosed with appendicitis in Group 2 (n=42) were compared as the final diagnostic criterion. RESULTS: The data of 139 patients with a mean age of 36.15 were evaluated statistically. IMA values were analyzed in both groups. The mean IMA of all patients was 0.74±0.16 AbsU. When the two groups were compared, it was seen that IMA was statistically higher in Group 1 than in the control group. While the area under the curve for IMA was 0.670, the sensitivity for the cutoff value of 0.715 was 68%, the specificity was 62%. CONCLUSION: Our study shows that IMA values provide significant results in predicting acute appendicitis.