High-fat diet induces anti-inflammatory effect in experimental colitis
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, cilt.61, ss.357-363, 2023 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61
- Basım Tarihi: 2023
- Doi Numarası: 10.56042/ijeb.v61i05.853
- Dergi Adı: INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, BIOSIS, CAB Abstracts, Directory of Open Access Journals
- Sayfa Sayıları: ss.357-363
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
The prevalence of ulcerative colitis, one of the inflammatory bowel diseases, has been increasing worldwide. Though fatty
diet leads to development of colitis, only little is known about the separate and combined effects of different fat compositions
and intermittent fasting, and the effects of preventative dietary changes on experimental colitis. In this study, we investigated
the effect of feeding type and frequency on the inflammation ulcerative colitis. Five groups, each comprising 7 male Wistar
albino rats, were formed viz. Colitis (as a control), High sucrose diet + Colitis, High sucrose diet + Intermittent fasting + Colitis,
High fat diet + Colitis, High fat diet + Intermittent fasting + Colitis. The intermittent fasting group (experimental group) was not
fed for 2 days (non-consecutive) in a week (except water), otherwise fed with ad libitum. Following the 7-wk feeding
application, the rats were treated with intrarectal administration of 4% acetic acid (pH 2.4). After the rats were sacrificed, the
levels of interleukin-1β, insulin, C-reactive protein, leptin, tumor necrosis factor-α, interleukin-6, insulin-like growth factor-1
and adiponectin were analyzed from the blood samples. Analyzes of results revealed a statistically significant decrease in
interleukin-1β, C-reactive protein, tumor necrosis factor-α, interleukin-6 and adiponectin levels in High sucrose diet
+ Intermittent fasting + Colitis and High fat diet + Intermittent fasting + Colitis groups (P<0.05). According to these findings,
the amount of fat and fatty acid composition in the fatty diet may have a protective effect against the development of colitis.
Intermittent fasting further enhances this protective effect by lowering proinflammatory cytokine levels and reducing systemic
inflammation in the body.