ASIAN JOURNAL OF SURGERY, vol.36, no.4, pp.165-169, 2013 (Journal Indexed in SCI)
Background/Objective: Chronic anal fissure is a painful condition that is associated with an increase in internal anal sphincter pressure. The main aim of this study is to evaluate the efficacy and adverse effects of topical isosorbide 5 mononitrate and topical diltiazem, when administered either as single agents or in combination, in the treatment of anal fissure.