Antioxidant effects of curcumin in spinal cord injury in rats Sıçanlarda spinal kord yaralanmsında curcuminin antioksidan etkileri
Ulusal Travma ve Acil Cerrahi Dergisi, vol.17, no.1, pp.14-18, 2011 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 17 Issue: 1
- Publication Date: 2011
- Doi Number: 10.5505/tjtes.2011.31391
- Journal Name: Ulusal Travma ve Acil Cerrahi Dergisi
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.14-18
- Keywords: Antioxidant, Curcumin, Malondialdehyde, Spinal cord injury, Superoxide dismutase
- Open Archive Collection: AVESIS Open Access Collection
- Ankara Yıldırım Beyazıt University Affiliated: No
Abstract
BACKGROUND This experimental study was performed to investigate the benefit of curcumin via its antioxidant effect on spinal cord injury (SCI) in rats. METHODS Twenty-four adult Wistar albino rats were randomized into three groups. SCI was performed by the weight-drop model. Group 1 underwent laminectomy followed by SCI and received no medication. Group 2 underwent laminectomy followed by SCI and received curcumin (200 mg/kg/day orally). Group 3 underwent laminectomy followed by SCI and received methylprednisolone (30 mg/kg intraperitoneally). Twenty-four hours later, blood samples were obtained from all rats; serum superoxide dismutase (SOD) and malondialdehyde (MDA) levels were determined, and the obtained results were compared. RESULTS SOD level in the curcumin group was higher than in the control group (p<0.000) and methylprednisolone group (p<0.012). MDA level in the curcumin group was lower than in the control group (p<0.042). Similarly, the MDA level in the methylprednisolone group was lower than in the control group (p<0.001). CONCLUSION The results of the present study show that curcumin effectively protects the spinal cord tissues against oxidative damage.