Association between hyponatremia, inflammation, and mortality in patients undergoing peritoneal dialysis: A nationwide observations

Erdogan B., Ata N., Caglayan M., GÖZÜKARA M. G., Gemcioglu E., Coskun F., ...More

Therapeutic Apheresis and Dialysis, vol.28, no.2, pp.265-271, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.1111/1744-9987.14092
  • Journal Name: Therapeutic Apheresis and Dialysis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Page Numbers: pp.265-271
  • Keywords: hyponatremia, mortality, peritoneal dialysis
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Introduction: Hyponatremia is the most common electrolyte disorder often present in peritoneal dialysis (PD) patients. The aim of this retrospective study was to investigate the effect of hyponatremia on mortality in patients undergoing PD. Methods: The health records of adult individuals with an inserted PD catheter identified via the centralized national e-health database were used. Results: The mean age of the 846 patients included in the study was 52.48 years (±14.6). The mean sodium level was 136.51 mEq/L. Sodium levels <137 mEq/L were associated with higher death risk independent of comorbidities. There was a 0.821 times less reduction in mortality for each mEq /L increase in serum sodium. Conclusion: Our study provides evidence that monitoring and adjusting serum sodium levels is crucial in managing PD patients with hyponatremia, as low serum sodium level was found to be a significant and independent predictor of mortality.