The Effect of Iron Replacement on Cognitive Functions in Reproductive Women with Iron Deficiency
KONURALP TIP DERGİSİ, cilt.15, sa.2, ss.175-181, 2023 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.18521/ktd.1148337
- Dergi Adı: KONURALP TIP DERGİSİ
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.175-181
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
Objective: Iron plays key role in brain development including neurogenesis, myelination, synaptic development, energy and neurotransmitter metabolism as well as normal brain functioning. The aim of this study is to examine the effect of iron replacement on cognitive functions in women with iron deficiency. Results: There was not a significant difference between the 1st MoCA scores of patients with ID or IDA in 165 women at the onset of the study. There was a significant increase in hemogram and ferritin levels of 81 patients who received a 200 mg/day iron replacement as expected (p<0.001). Cognitive functions were found to be significantly lower in single women with a high education level and a low body mass index (p<0.001). Average pretreatment MoCA score was 21 (min: 18- max:21), whereas post treatment average score was 26 (min:23- max:27) (p<0.001). For all cognitive functions, subgroup scores significantly increased after treatment. This improvement in cognitive functions was determined independently of demographic data. A low negative correlation also was found between age and total cognitive function score (r:-0.335, p <0.001). Conclusions: In this study, we observed that after replacement therapy there was a significant increase in total and subgroup scores corresponding to cognitive functions of women diagnosed as iron deficiency or anemia. Considering the effect of iron replacement therapy on cognitive functions in women in the reproductive period, it should not be neglected.