Serum Thiol/Disulphide Homeostasis in Preeclampsia.

Ozler S., EREL Ö. , Oztas E., Ersoy A. O. , Ergin M. , Sucak A., ...More

Hypertension in pregnancy, vol.34, no.4, pp.474-485, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3109/10641955.2015.1077859
  • Title of Journal : Hypertension in pregnancy
  • Page Numbers: pp.474-485


Objective: To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate the association with clinical parameters. Methods: Forty-three pregnant women with preeclampsia and 43 healthy, uncomplicated pregnancies were included in the study. Native thiol, disulphide, and total thiol concentrations were measured by a novel automated method. Results: The serum native and total thiol levels were significantly lower in preeclampsia when compared with the healthy group (p<0.001). There were significant correlations among the homeostatic parameters and preeclampsia. Conclusion: Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.