Serum Thiol/Disulphide Homeostasis in Preeclampsia.


Ozler S., EREL Ö. , Oztas E., Ersoy A. O. , Ergin M. , Sucak A., ...Daha Fazla

Hypertension in pregnancy, cilt.34, sa.4, ss.474-485, 2015 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/10641955.2015.1077859
  • Dergi Adı: Hypertension in pregnancy
  • Sayfa Sayıları: ss.474-485

Özet

Objective: To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate the association with clinical parameters. Methods: Forty-three pregnant women with preeclampsia and 43 healthy, uncomplicated pregnancies were included in the study. Native thiol, disulphide, and total thiol concentrations were measured by a novel automated method. Results: The serum native and total thiol levels were significantly lower in preeclampsia when compared with the healthy group (p<0.001). There were significant correlations among the homeostatic parameters and preeclampsia. Conclusion: Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.