Respiratory support duration and the association between patent ductus arteriosus exposure and bronchopulmonary dysplasia

OKULU, EMEL; ERDEVE, ÖMER; Arslan, Zehra; DEMİREL, NİHAL; Akcan, Abdullah; Erdogan, Funda; BÜLBÜL, Ali; USLU, Hasan; Oncel, Mehmet; ÖZKAN, HİLAL; KÖKSAL, FATMA; Koc, Esin; Mutlu, Mahmut; Kader, Sebnem; Tuncer, Oguz; Celik, Tolga; Ozlu, Ferda; Aslanoglu, Sertac; Ozumut, Sibel; YOZGAT, Yılmaz; Bayraktar, Bilge; ÇALKAVUR, Şebnem; Ergenekon, Ebru; Celik, Yalcin; Armangil, Didem; BÜYÜKKALE, Gökhan; Cetinkaya, Merih; Ozdemir, Ozmert; Ergin, Hacer; Ertugrul, Sabahattin; Yalinkilic, Derya; Celik, Kıymet; Gokce, Ismail; Kaya, Huseyin; KARA, Mustafa; TEKGÜNDÜZ, Kadir

doi:10.1038/s41372-026-02934-0

Respiratory support duration and the association between patent ductus arteriosus exposure and bronchopulmonary dysplasia

OKULU E., ERDEVE Ö., Arslan Z., DEMİREL N., Akcan A. B., Erdogan F. T., ...Daha Fazla

Journal of Perinatology, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2026
Doi Numarası: 10.1038/s41372-026-02934-0
Dergi Adı: Journal of Perinatology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

Objective: To determine whether the association between prolonged patent ductus arteriosus (PDA) exposure and bronchopulmonary dysplasia (BPD) differs according to the duration of invasive respiratory support in very preterm infants. Study design: This secondary analysis of the multicenter, prospective INTERPDA cohort included infants born at <29 weeks’ gestation with moderate-to-large PDA requiring respiratory support. Infants were stratified according to PDA exposure duration ( < 14 and ≥14 days) and cumulative invasive respiratory support duration ( < 10 and ≥10 days). Results: Among 363 infants, prolonged PDA exposure was associated with higher rates of moderate/severe BPD, BPD or death, and mortality only in infants requiring ≥10 days of respiratory support. In adjusted analyses, prolonged PDA exposure remained independently associated with these adverse outcomes. Conclusion: Prolonged PDA exposure was associated with adverse pulmonary outcomes primarily in infants with prolonged respiratory dependence, supporting an individualized, physiology-based approach to PDA management in very preterm infants.