Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension


Ates I., Ozkayar N., Ivan B., Yilmaz F. M. , Topcuoglu C., NEŞELİOĞLU S. , ...More

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, vol.10, no.2, pp.159-166, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jash.2015.12.008
  • Title of Journal : JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
  • Page Numbers: pp.159-166

Abstract

We aimed to investigate the thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension with a novel and automated method. Blood thiol/disulphide homeostasis, which consists of native thiol/disulphide exchanges, was investigated in 45 patients with primary hypertension and 45 healthy controls. The levels of native thiol, total thiol, and native thiol/total thiol ratio were lower while the disulphide level and disulphide/native thiol and disulphide/total thiol ratios were higher in patients with primary hypertension when compared with those in the control group. Positive correlation was detected between 24-hour systolic and diastolic blood pressure levels and disulphide/native thiol ratio. With reference to the stepwise multiple linear regression model; increase in disulphide/native thiol ratio and log(24-hour urine microalbumin) and decrease in native thiol/total thiol ratio are independent predictors of 24-hour systolic and diastolic blood pressure. This study demonstrated that thiol/disulphide homeostasis was shifted toward disulphide formation in patients with primary hypertension. (C) 2016 American Society of Hypertension. All rights reserved.