Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus
Journal of Women's Health, cilt.18, sa.9, ss.1435-1439, 2009 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 9
- Basım Tarihi: 2009
- Doi Numarası: 10.1089/jwh.2008.1213
- Dergi Adı: Journal of Women's Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Sayfa Sayıları: ss.1435-1439
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM). Methods: Paraoxonase and arylesterase activities, and LOOH levels were assessed for GDM cases (n= 55) and controls (n=59). Serum basal and salt-stimulated paraoxonase and arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Results: Basal and salt-stimulated paraoxonase and arylesterase activities were significantly lower (p= 0.002, p=0.004; and p =0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p <0.001). Among gestational diabetes patients, serum paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r=-0.390, p =0.003; and r= -0.287, p= 0.034, respectively). Conclusions: Findings of the present study have shown that serum paraoxonase and arylesterase activities are significantly reduced in women with GDM. Decreased serum paraoxonase and arylesterase activities might play a role in the potential early pathogenesis for atherosclerotic heart disease in GDM beyond their antioxidant properties. © 2009 Mary Ann Liebert, Inc.