Parvovirus B19 infection reminiscent of myelodysplastic syndrome in three children with chronic hemolytic anemia

Yarali N., Duru F., Sipahi T., Kara A., Tezic T.

Pediatric Hematology and Oncology, vol.17, no.6, pp.475-482, 2000 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2000
  • Doi Number: 10.1080/08880010050120836
  • Journal Name: Pediatric Hematology and Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.475-482
  • Keywords: MDS, Pancytopenia, Parvovirus B19
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

The authors have seen transient pancytopenia with erythroid hypoplasia and striking trilineage myelodysplasia reminiscent of true myelodysplastic syndrome (MDS) in 3 children, 1 with thalassemia intermedia and the other 2 with previously undiagnosed hereditary spherocytosis. In these 3 children transient pancytopenia and myelodysplasia coincided with serological evidence of acute parvovirus-B19 (PV-B19) infection, strongly suggesting their relevance. It is of interest that these 3 cases were encountered within a period of 6 months. This might be an incidental event, but it might also be concluded that acute PV-B19 infection associated transient pancytopenia with morphological appearance of MDS may occur more frequently than reported in the literature. So, PV-B19-associated nonclonal MDS should be considered in the differential diagnosis of true clonal MDS.