Background/Aim: The aim of this study was to investigate the effects of celiac disease on cardiac functions using tissue Doppler echocardiography (TDE). Patients and Methods: The study included 30 patients with celiac disease (CD) and 30 healthy volunteers. Echocardiographic examinations were assessed by conventional echocardiography and tissue Doppler imaging. The peak systolic velocity (S(')m), early diastolic myocardial peak velocity (E(')m), late diastolic myocardial peak velocity (A(')m), E(')m/A(')m ratio, myocardial precontraction time (PCT(')m), myocardial contraction time (CT(')m), and myocardial isovolumetric relaxation time (IVRT(')m), E to E(')m ratio were measured. Results: In pulsed wave Doppler echocardiography, mitral late diastolic flow (A) velocity and E to E(')m ratio were significantly higher (P = 0.02 and P = 0,017), E/A ratio was significantly lower (P = 0.008) and IVRT was significantly prolonged (P = 0.014) in patients with CD. In TDE, S(')m, E(')m, and E(')m/A(')m ratio were significantly lower, IVRT(')m was longer (P = 0.009) from septal mitral annulus and S(')m, E(')m, E(')m/A(')m ratio were significantly lower, PCT(')m, PCT/ET ratio, IVRT(')m were longer, and MPI was higher from lateral mitral annulus in celiac group than controls. Conclusion: Our study confirms that patients with CD have impaired diastolic function. More importantly, we also demonstrated an impairment of myocardial systolic function in patients with CD by TDE. We recommend using TDE in addition to conventional echocardiography parameters for the cardiovascular risk assessment of patients with CD.