Serum sialic acid, hs-CRP and oxidative stress parameters in obese children


Yilmaz F. M. , Yilmaz G., Erdeve Ş. S. , Dallar Y., Topkaya B., YÜCEL D.

Journal of Pediatric Endocrinology and Metabolism, vol.20, no.2, pp.205-210, 2007 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1515/jpem.2007.20.2.205
  • Journal Name: Journal of Pediatric Endocrinology and Metabolism
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.205-210
  • Keywords: Child, hs-CRP, Obesity, Oxidative stress, Sialic acid

Abstract

Background: Obesity is a common health problem that is rapidly increasing among children. Obesity is accompanied by a high incidence of atherosclerosis, arterial hypertension and type 2 diabetes mellitus. We tested the hypothesis that the risk for atherosclerosis may be increased in obese children and measured some risk factors for atherosclerosis. Patients and Methods: We determined sialic acid levels and investigated correlations with malondialdehyde (MDA), susceptibility to oxidation, total thiol concentrations, glucose and lipid profile in 39 obese (BMI 26.6 ± 3.9) and 33 sex- and age-matched healthy children (BMI 15.9 ± 1.7). Results: MDA concentrations, susceptibility to oxidation and hs-CRP were significantly higher in obese children than controls. Sialic acid and total thiol concentrations were higher in controls but this did not reach statistical significance. Total cholesterol, LDL-cholesterol and glucose concentrations were significantly higher in the obese group and there was a positive correlation between BMI and MDA, susceptibility to oxidation, hs-CRP and glucose concentrations, and a negative correlation between BMI and HDL-cholesterol. Although sialic acid levels were not different between the groups, they showed a correlation with hs-CRP. Conclusions: A higher risk was found in obese children in relation to oxidative stress parameters, hs-CRP and lipid profile, and this risk showed a positive correlation with BMI. These results are important because children will encounter this increased risk for a longer time than adults, and taking care of obesity in childhood is especially important. © Freund Publishing House Ltd.