Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models

Rodrigues-Braz D., Zhao M., Yeşilırmak N. , Aractingi S., Behar-Cohen F., Bourges J.

Molecular Vision, vol.13, no.27, pp.323-353, 2021 (Journal Indexed in SCI)

  • Publication Type: Article / Review
  • Volume: 13 Issue: 27
  • Publication Date: 2021
  • Title of Journal : Molecular Vision
  • Page Numbers: pp.323-353


Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring factors, the pathogenesis of which remains imperfectly understood. Recognized mechanisms include the innate immune system, with the implication of Toll-like receptors (TLRs) and cathelicidins; neurovascular deregulation involving vascular endothelial growth factor (VEGF), transient receptor potential (TRP) ion channels, and neuropeptides; and dysfunction of skin sebaceous glands and ocular meibomian glands. Microorganisms, genetic predisposition, corticosteroid treatment, and ultraviolet B (UVB) radiation are favoring factors. In this paper, we review the common and specific molecular mechanisms involved in the pathogenesis of cutaneous and ocular rosacea and discuss laboratory and clinical studies, as well as experimental models.