The Effect of Varying Doses of Intravenous Paracetamol on the Electrical Activity of the Brain in Penicillin-Induced Status Epilepticus in Rats
EPILEPSI, cilt.21, sa.1, ss.13-19, 2015 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.5505/epilepsi.2015.30085
- Dergi Adı: EPILEPSI
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.13-19
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objectives: Paracetamol is a widely used analgesic and antipyretic agent. It has been reported that N-arachidonoyl-phenolamine, the active metabolite of paracetamol, reduces epilepsy by activating the endocannabinoid system in some models of experimental epilepsy. Diazepam is a benzodiazepine well known to have anticonvulsant effects. The aim of the present study was to investigate the effects of different doses of paracetamol on penicillin-induced epileptiform activity (PIEA) in rats.