The Effect of Varying Doses of Intravenous Paracetamol on the Electrical Activity of the Brain in Penicillin-Induced Status Epilepticus in Rats

Mumcuoglu I., Kurt S., Aydin D., Ekici F., Kasap Z., Solmaz V., ...More

EPILEPSI, vol.21, no.1, pp.13-19, 2015 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5505/epilepsi.2015.30085
  • Journal Name: EPILEPSI
  • Journal Indexes: Emerging Sources Citation Index, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.13-19


Objectives: Paracetamol is a widely used analgesic and antipyretic agent. It has been reported that N-arachidonoyl-phenolamine, the active metabolite of paracetamol, reduces epilepsy by activating the endocannabinoid system in some models of experimental epilepsy. Diazepam is a benzodiazepine well known to have anticonvulsant effects. The aim of the present study was to investigate the effects of different doses of paracetamol on penicillin-induced epileptiform activity (PIEA) in rats.