Serum amyloid A levels are increased in pre-eclampsia

Engin-Üstün Y., Üstün Y., Karabulut A., Özkaplan E., Meydanli M. M., Kafkasli A.

Gynecologic and Obstetric Investigation, vol.64, no.2, pp.117-120, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1159/000100329
  • Journal Name: Gynecologic and Obstetric Investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.117-120
  • Keywords: Inflammation, Pre-eclampsia, Serum amyloid A
  • Ankara Yıldırım Beyazıt University Affiliated: No


Aim: The purpose of this study was to examine serum amyloid A (SAA) levels in normal pregnant and pre-eclamptic women. Methods: SAA levels were measured in 25 normotensive and 25 pre-eclamptic pregnant women by enzyme linked immuno-sorbent assay. Results: In pre-eclampsia, SAA level and C-reactive protein (CRP) averaged 28.2 (7.2-135) ng/l and 21 (6.13-91) mg/l, respectively, which were significantly higher than those of normal pregnancy (7.8 [4.65-24.6] ng/l and 6.05 [0.3-19] mg/l, respectively) (p < 0.05). In addition, SAA level was positively correlated to CRP (r = 0.468, p < 0.05). Conclusion: Marked increases of both SAA level and CRP in pre-eclampsia, and their inter-relation, may at least in part contribute to the pathogenesis of pre-eclampsia. Copyright © 2007 S. Karger AG.