RELATIONSHIP BETWEEN INFLAMMATIONMARKER CRP ALBUMIN RATIO AND OBESITY,SARCOPENIA AND SARCOPENIC OBESITY
6.ULUSLARARASI VE 17. AKADEMİK GERİATRİ KONGRESİ, Muğla, Türkiye, 16 - 20 Ekim 2024, ss.65, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Muğla
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.65
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Background/Aim: Sarcopenic obesity (SO) is a syndrome that changes with the combined dissociation of body fat and muscle loss, more important in geriatric age groups (1).The incidence of sarcopenic obesity is rapidly increasing due to the aging of the worldwide population and the current obesity epidemic. (2). The pathogenesis of sarcopenic obesity is complex, multifactorial and comprehensively elucidated. Low-grade treatment has an important role in the pathogenesis of sarcopenia, obesity and sarcopenic obesity (3). Inflammatory changes such as white adipose tissue, macrophages, inflammatory T lymphocytes promote the secretion of proinflammatory cytokines that facilitate the breakdown not only in adipose tissue but also in muscle tissue. In the chronic period, CRP increases while albumin decreases, so the CRP/albumin ratio (CAR) may be a more sensitive determinant than CRP or albumin levels analyzed separately (4,5). The increase in high CAR level is associated with inflammatory burden, poor prognosis and mortality (6).The relationship between inflammatory marker CAR levels in obesity and sarcopenic obesity has not been evaluated so far. Methods:This croSS-sectional retrospective study included 249 patients aged 65 years and over who applied to our geriatric clinic. Patients with infection, rheumatic disease, and active malignancy were excluded. Katz Index of Activities of Daily Living (ADL), Lawton Instrumental Activities of Daily Living Scale (IADL),, mini-nutrition assessment short form (MNA-SF), geriatric depression scale (GDS), mental status examination (MMSE) tests were applied to the patients. We defined SO according to the definition and diagnostic criteria of ESPEN (European Society of Clinical Nutrition and Metabolism) and EASO (European Association for the Study of Obesity). We used chi-square and one-way ANOVA tests for inter-group evaluation. Results: We included 249 patients in our study, 43 (%13) obese patients, 51 (%20.5) sarcopenic patients, 55 (%22.1) sarcopenic obese (SO) patients and 100 (%40.29) healthy controls. There were more women than men in both groups; However, there was no significant difference between the gender distributions between the groups. The age of the SO group was higher, hypertension and diabetes were more common. We found that cognitive test scores, daily life activities and nutrition scores were worse than the SO groups. We found that the albumin level of the SO group was significantly lower (p= 0.005). The CAR level was in the highest obesity classes in all three group comparisons (p=0.015). In the determination of obesity, the AUC value was .550 (p= .301) in the evaluation with the ROC curve. No significant relationship was detected. Conclusion: Sarcopenia and obesity are different conditions, but they share common pathophysiology and risks such as lifestyle, maturation, inflammatory cytokines, reactive oxygen species production and endocrine changes. In our study, we found high CAR levels in the obesity group, but not in the sarcopenia and SO groups.This supported the role of inflammation in obesity pathology, but the lack of a significant relationship between CAR levels and sarcopenia and sarcopenic obesity suggested that obesity and other accompanying diseases are more prominent in inflammation than sarcopenia. Additional research is needed on this subject. Keywords: sarcopenia, obesity, sarcopenic obesity, CRP, albumin, CRP/ albumin, inflammation References 1.Donini, L. M., Busetto, L., Bischoff, S. C., Cederholm, T., BallesterosPomar, M. D., Batsis, J. A., Barazzoni, R. (2022). Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement. Obesity facts, 15(3), 321-335. 2. Wei, S., Nguyen, T. T., Zhang, Y., Ryu, D., & Gariani, K. (2023). Sarcopenic obesity: Epidemiology, pathophysiology, cardiovascular disease, mortality, and management. Frontiers in Endocrinology, 14, 1185221 3. Majno G., Joris I. Cells, Tissues and Disease. Oxford University Press; New York, NY, USA: Oxford, UK: 2004 4. He Y, Tang J, Wu B, Yang B, Ou Q, Lin J (2019) Correlation between albumin to fibrinogen ratio, C-reactive protein to albumin ratio and Th17 cells in patients with rheumatoid arthritis. 5.Kahraman, S., Dogan, A. C., Demirci, G., Demir, A. R., Yilmaz, E., Agus, H. Z., ... & Erturk, M. (2019). The prognostic value of C-reactive protein to albumin ratio in patients with isolated degenerative aortic valve stenosis undergoing surgical aortic valve replacement. Brazilian Journal of Cardiovascular Surgery, 35, 299-306. 6. Ranzani, O. T., Zampieri, F. G., Forte, D. N., Azevedo, L. C. P., & Park, M. (2013). C-reactive protein/albumin ratio predicts 90-day mortality of septic patients. PloS one, 8(3), e59321.