Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients?


Kesimci E., Coskun E., Ugur G., Muderris T., İZDEŞ S. , KARAHALİL B.

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION, vol.45, no.5, pp.264-269, 2017 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.5152/tjar.2017.09475
  • Title of Journal : TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
  • Page Numbers: pp.264-269

Abstract

Objective: Volatile anaesthetics can inhibit the bronchociliary clearence in a dose-and time-dependend way. Moreover, they can have potential mutagenic/carcinogenic effects under chronic exposure. A genotoxicity test-micronuclei assay-was carried out in nasal epithelial cells to analyze the genotoxic effect of sevoflurane in adult patients undergoing general anesthesia.