Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients?

Kesimci, Elvin; Coskun, Erdem; Ugur, Gokcer; Muderris, Togay; İZDEŞ, SEVAL; KARAHALİL, BENSU

doi:10.5152/tjar.2017.09475

Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients?

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Kesimci E., Coskun E., Ugur G., Muderris T., İZDEŞ S., KARAHALİL B.

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION, vol.45, no.5, pp.264-269, 2017 (ESCI)

Publication Type: Article / Article
Volume: 45 Issue: 5
Publication Date: 2017
Doi Number: 10.5152/tjar.2017.09475
Journal Name: TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.264-269
Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Objective: Volatile anaesthetics can inhibit the bronchociliary clearence in a dose-and time-dependend way. Moreover, they can have potential mutagenic/carcinogenic effects under chronic exposure. A genotoxicity test-micronuclei assay-was carried out in nasal epithelial cells to analyze the genotoxic effect of sevoflurane in adult patients undergoing general anesthesia.