EVALUATION OF THE RELATIONSHIP BETWEEN HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS AND COMMUNITY-ACQUIRED PNEUMONIA SEVERITY IN ADULT PATIENTS


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Hezer H., Parlak E. S. , ALKAN A. , HASANOĞLU H. C. , ARGÜDER E. , Öztürk B., ...More

Ankara Medical Journal, no.1, pp.118-128, 2022 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.5505/amj.2022.98957
  • Title of Journal : Ankara Medical Journal
  • Page Numbers: pp.118-128
  • Keywords: biomarker, Community-acquired pneumonia, high-density lipoprotein cholesterol

Abstract

© 2022 Academic Publishing House. All rights reserved.Objectives: Inflammation and acute phase reactions lead to altered high-density lipoprotein cholesterol (HDL-C) concentrations. This study aimed to evaluate HDL-C levels in community-acquired pneumonia (CAP) and to determine the predictive value of disease severity in CAP. Materials and Methods: This prospective study was conducted in the Department of Pulmonary Diseases. One hundred twenty-five adult patients with CAP were included in the study. Patients were classified into three groups as follows: Group 1; outpatients, Group 2; hospitalized patients and Group 3; patients admitted to the intensive care unit. C-reactive protein (CRP), procalcitonin (PCT) and HDL-C levels were evaluated at baseline, 7th and 30th days in all CAP patients. The relationship between CRP, PCT and HDL-C levels was investigated. Diagnostic performance of baseline HDL-C levels was assessed using receiver-operating characteristic (ROC) curve analyses. Results: HDL-C levels were found to be decreased in all groups compared to their normal ranges. There was a significantly negative correlation between HDL-C and CRP and PCT (Spearman's r=-0.557, r=-0.841, respectively; p< 0.001). The sensitivity and specificity of HDL-C cut-off value were 0.738 (95% CI=0.580-0.861) and 0.875 (95% CI=0.732-0.958), with an overall accuracy of 0.861 (95% CI=0.728-0.935). Conclusion: HDL-C levels can be used as an acute phase reactant in patients with CAP.