Perioperative D-dimer levels and head and neck cancer surgery: a prospective observational study
Turkish Journal of Biochemistry, cilt.50, sa.2, ss.250-255, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.1515/tjb-2024-0236
- Dergi Adı: Turkish Journal of Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Food Science & Technology Abstracts, Directory of Open Access Journals
- Sayfa Sayıları: ss.250-255
- Anahtar Kelimeler: cancer, neck dissection, surgery, thrombosis, venous thromboembolism
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objectives: D-dimer molecules are formed as a result of fibrinolysis and elevation of D-dimer levels are suggestive for thrombosis. The elevation of D-dimer levels and its correspondence with thromboembolism in orthopedic and general surgeries are well studied, but there are only a few studies in literature that investigates this issue in head and neck surgery. We aimed to investigate D-dimer levels and its course throughout the perioperative period in patients who underwent head and neck cancer surgery. Methods: We conducted a prospective, observational study in patients who underwent neck dissection along with primary tumor resection in our otorhinolaryngology clinic between January 2022 and June 2023. D-dimer levels were measured from blood samples preoperatively and post-operatively days 0–7 and on postoperative 14th day. D-dimer levels were compared statistically. Results: Twenty-one patients were included in the study. D-dimer values peaked on the first day then gradually decreased and reached a level slightly below 2 times of the preoperative values on the 14th day. The change in D-dimer levels between preoperative and postoperative days 1–14 was statistically significant. The difference between D-dimer levels measured on each day of the first week and levels on 14th day was found to be significant. Also, difference of D-Dimer levels between postoperative day 0 and day 7 was statistically significant. Conclusions: The trend of D-Dimer levels following surgery in head and neck cancer patients may prove useful in clinical practice to rule out thrombotic events, in accordance with other risk factors and symptomatology.