The Investigation of Plasma Glucagon-like Peptide-1 Levels in Newly Diagnosed Type 1 Diabetic Children.

B U., Gürbüz F., F T., B Y., N M., Ak T.

WEST INDIAN MEDICAL JOURNAL, vol.65, no.1, pp.141-146, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.7727/wimj.2014.134
  • Journal Name: WEST INDIAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.141-146
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Abstract

Objective: To reveal the possible role of glucagon-like peptide-1 (GLP-1) in newly diagnosed Type 1 diabetic children.

Methods: Twenty-five newly diagnosed children and 22 healthy children were included in the study.

Results: In oral glucose tolerance tests, no correlation was observed between C-peptide and GLP-1 levels at 0 and 30 minutes, and plasma GLP-1 levels in both groups at 0 and 30 minutes were not statistically different.

Conclusion: Consequently, fasting and postprandial GLP-1 levels in newly diagnosed Type 1 diabetic children are not different from healthy children. Glucagon-like peptide-1 levels in newly diagnosed Type 1 diabetic children suggest that plasma GLP-1 levels do not have any role in the pathogenesis of Type 1 diabetes mellitus.