Increased adenosine deaminase in hydatidiform mole

Engin-Üstün Y., Üstün Y., Karabulut A., Doǧan K., Meydanli M. M., Sezgin B.

Clinical Chemistry and Laboratory Medicine, vol.45, no.1, pp.78-81, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1515/cclm.2007.010
  • Journal Name: Clinical Chemistry and Laboratory Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.78-81
  • Keywords: Adenosine deaminase, Hydatidiform mole
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

Background: The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole. Methods: Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers. Results: Mean adenosine deaminase activity in the hydatidiform mole group was 121.5±24.8 U/L, significantly higher than in the pregnant control (7.8±6.5 U/L; p<0.0001) and non-pregnant control groups (6.4±7.4 U/L; p<0.0001). A cutoff level of 40.5 U/L was found, with both sensitivity and specificity of 100%. Conclusions: Adenosine deaminase may play a role in the development of hydatidiform mole. © 2007 by Walter de Gruyter.