Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome

Akkus O., Kaypakli O., Koca H., Topuz M., Kaplan M., Baykan A. O., ...More

BIOMARKERS IN MEDICINE, vol.12, no.4, pp.349-358, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.2217/bmm-2017-0372
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.349-358
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Aim: The aim of this study was to evaluate whether ranging values of thiol and disulphide herald a dilatation or impending acute aortic syndrome at thoracic aorta. Results/methodology: Study population consisted of patients with aortic aneurysm (n = 58), with acute aortic syndrome (n = 32) and without aortic aneurysm (control group; n = 61). A spectrophotometric method was used to determine thiol and disulphide. Native and total thiol levels were moderately correlated with maximal aortic diameter. At the end of 6 months, there was statistically significant increase in native, total thiol levels and decrease in disulfide and disulphide/native thiol ratio in operated group. Discussion/conclusion: Lower thiol levels may be associated with the higher risk of aortic aneurysm development and may increase after surgical therapy.