Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome
BIOMARKERS IN MEDICINE, cilt.12, sa.4, ss.349-358, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 4
- Basım Tarihi: 2018
- Doi Numarası: 10.2217/bmm-2017-0372
- Dergi Adı: BIOMARKERS IN MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.349-358
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Aim: The aim of this study was to evaluate whether ranging values of thiol and disulphide herald a dilatation or impending acute aortic syndrome at thoracic aorta. Results/methodology: Study population consisted of patients with aortic aneurysm (n = 58), with acute aortic syndrome (n = 32) and without aortic aneurysm (control group; n = 61). A spectrophotometric method was used to determine thiol and disulphide. Native and total thiol levels were moderately correlated with maximal aortic diameter. At the end of 6 months, there was statistically significant increase in native, total thiol levels and decrease in disulfide and disulphide/native thiol ratio in operated group. Discussion/conclusion: Lower thiol levels may be associated with the higher risk of aortic aneurysm development and may increase after surgical therapy.