Assessment of the relationship between asthma severity and cardiac functions using speckle tracking in pediatric patients
Journal of Asthma, cilt.63, sa.2, ss.169-178, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/02770903.2025.2581006
- Dergi Adı: Journal of Asthma
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Psycinfo
- Sayfa Sayıları: ss.169-178
- Anahtar Kelimeler: Asthma, asthma severity, cardiac strain, echocardiography, pediatric, tissue Doppler
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: The long-term effects of childhood asthma on cardiac functions remain unclear. This study evaluates the relationship between asthma severity and cardiac function in pediatric asthma patients. Methods: Children aged 10–18 years with at least five years of asthma follow-up and no known cardiac disease were included. A control group of healthy children with no chronic diseases participated. Both groups underwent electrocardiography, conventional echocardiography, tissue Doppler examination (TDI), and 2D speckle tracking echocardiography (2D-STE). Results: A total of 113 asthma patients (59 mild, 54 moderate-severe) and 59 controls were assessed. Compared to controls, the asthma group had increased right ventricular area (RVA) (p = 0.04), while interventricular septal and left ventricular S’ velocity (IVSS’, LVS’) and right ventricular late diastolic velocity (RVA’) were lower (p = 0.04, p = 0.04, p = 0.02, respectively). Conventional and TDI parameters showed no other significant differences. In 2D-STE measurements, left ventricular global longitudinal and circumferential strain (LVGLS, LVGCS), right ventricular global longitudinal strain (RVGLS), and right atrial reservoir strain (RARS) were lower (p = 0.01, p = 0.03, p = 0.01, p = 0.01, respectively), while left ventricular global longitudinal and circumferential strain rate (LVGLSR, LVGCSR), right ventricular global longitudinal strain rate (RVGLSR), and right atrial reservoir strain rate (RARSR) were higher (p = 0.04, p = 0.04, p = 0.03, p = 0.04, respectively) in the asthma group, with more pronounced differences in the moderate-severe asthma group. Conclusion: Our study shows a decrease in both systolic and diastolic functions in both ventricles and right atrium in relation to the severity of childhood asthma, and 2D-STE can be useful in identifying early changes.