Assessment of oxidative stress markers in recurrent pregnancy loss: A prospective study
Archives of Gynecology and Obstetrics, cilt.289, sa.6, ss.1337-1340, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 289 Sayı: 6
- Basım Tarihi: 2014
- Doi Numarası: 10.1007/s00404-013-3113-4
- Dergi Adı: Archives of Gynecology and Obstetrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1337-1340
- Anahtar Kelimeler: Oxidative stress, Recurrent pregnancy loss, Total antioxidant level, Total oxidant level
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective To determine the levels of oxidative stress markers in recurrent pregnancy loss using a novel automated method. Materials and methods 30 pregnant women in their first trimester with a history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. Total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in maternal serum were measured using the more recently designated Erel method. Results We observed statistically significant increased TOL and OSI levels in patient group (p = 0.032, p = 0.007, respectively). We also demonstrated statistically significant decreased TAC in pregnant women who had a history of RPL (p = 0.013). Conclusion Our results support the concept that oxidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAC, TOL, OSI levels using Erel method are needed. © Springer-Verlag 2013.