Serum Ischemia-modified albumin levels in mild to moderate rosacea: an exploratory case-control study
Cutaneous and Ocular Toxicology, cilt.45, sa.3, ss.498-506, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/15569527.2026.2692382
- Dergi Adı: Cutaneous and Ocular Toxicology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Environment Index, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.498-506
- Anahtar Kelimeler: biomarker, exploratory study, ischemia-modified albumin, oxidative stress, persistent erythema, Rosacea
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Background: Rosacea is a chronic inflammatory dermatosis in which oxidative stress has been implicated as a pathogenic factor. Ischemia-modified albumin (IMA) is a serum biomarker of oxidative stress not previously evaluated in rosacea. Objective: To explore serum IMA levels in rosacea patients versus healthy controls and examine associations with disease severity and clinical characteristics. Methods: In this exploratory case-control study, 72 rosacea patients and 72 age- and sex-matched healthy controls were enrolled. Serum IMA was measured by the albumin cobalt-binding (ACB) colorimetric method with concurrent serum albumin measurement. Statistical analysis included between-group comparisons, Benjamini–Hochberg false discovery rate (FDR) correction, and multivariable linear regression Results: Mean serum IMA did not differ significantly between rosacea patients (0.72 ± 0.19 ABSU) and controls (0.74 ± 0.14 ABSU; mean difference −0.02 ABSU, 95% CI [−0.08, +0.04]; Cohen’s d = 0.12; p = 0.32). Serum albumin was also comparable between groups (p = 0.50). Male patients showed higher IMA than females (0.81 ± 0.13 vs. 0.72 ± 0.17 ABSU; mean difference +0.09 ABSU, 95% CI [+0.01, +0.17]; Cohen’s d = 0.55; p = 0.015). A weak positive correlation between persistent erythema severity and IMA was observed (Spearman’s r = 0.24, 95% CI [+0.01, +0.45]; p = 0.045), which did not retain significance after FDR correction (p = 0.058). Multivariable regression revealed no independent predictor of IMA. Conclusion: erum IMA was not significantly elevated in rosacea. Exploratory findings suggest possible associations with male sex and erythema severity, warranting confirmation in larger phenotype-stratified studies.