The role of preoperative serum thyroglobulin and thyroid auto-antibody levels before histopathological diagnosis of thyroid cancers Tiroid kanserlerinin histopatolojik tanı öncesinde serum tiroglobülin ve tiroid oto-antikorları seviyelerinin rolü
Turkish Journal of Medical Sciences, cilt.41, sa.3, ss.487-493, 2011 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.3906/sag-1011-1
- Dergi Adı: Turkish Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.487-493
- Anahtar Kelimeler: Anti-thyroid antibodies, Th yroid cancers, Thyroglobulin
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Aim: If a frozen section pathological examination is not performed in unilateral thyroid nodule surgery and the postoperative pathological diagnosis is cancer, a second operation may be required. Therefore, it was studied whether serum thyroid auto-antibody levels are useful or not in determining preoperative malignancy in patients with thyroid disorders. Materials and methods: It was investigated retrospectively whether there was a correlation between preoperative serum thyroglobulin (Tg), anti-thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase antibody (anti-TPO) levels and thyroid cancer in patients who had undergone thyroidectomy. Results: Two hundred and eighty-seven patients who had undergone thyroid surgery and whose preoperative serum levels of Tg, anti-Tg, and anti-TPO had been recorded were included in this study. Only 54 (18.8%) of the patients had a malignant diagnosis in the postoperative histopathological examination. Sixteen of the patients who had a postoperative malignant thyroid disease diagnosis (29.6%) had high serum Tg, anti-TPO, and/or anti-Tg levels. The rate of high serum Tg levels was signifi cant in patients with a benign pathology (49.4% vs. 31.5%, P = 0.018). Conclusion: It appears that preoperative measurement of serum Tg, anti-TPO, and anti-Tg levels is not a useful method to predict malign thyroid diseases. © Tübitak.