Investigation of risk factors and high-sensitive C-reactive protein levels in patients with Leriche syndrome concomitant coronary artery disease and significant carotid stenosis
Turkiye Klinikleri Cardiovascular Sciences, cilt.22, sa.1, ss.19-24, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 1
- Basım Tarihi: 2010
- Dergi Adı: Turkiye Klinikleri Cardiovascular Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.19-24
- Anahtar Kelimeler: Atherosclerosis, C-reactive protein, leriche syndrome, Carotid artery diseases, Coronary artery disease
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: Clinical manifestations of atherosclerosis are coronary artery disease (CAD), cerebrovascular disease, and peripheral artery disease. The most advanced clinical form of atherosclerosis is involvement of all the three vascular beds. The aim of the present study is analysis of risk profiles and detection of high-sensitive C-reactive protein (hsCRP) levels of patients with Leriche syndrome concomitant CAD and severe carotid stenosis. Material and Methods: Twenty-one patients, who were followed in our clinic with Leriche syndrome and detected CAD and severe carotid stenosis, were recruited as study group. Control group consisted of 25 patients with only CAD who were matched to the study group for age and sex. Results: While 85.7% of the patients in the study group had three or more risk factors, this rate was only 36% in the control group (p=0.004). Of the patient in the study group, 95.2% were male, 76.2% were hypertensive, and 38.1% were diabetic. It was remarkable that, in the study group, smoking habit was more (90.5% and 52%, respectively; p= 0.02), and HDL-cholesterol levels were lowest (27.2 ± 3.5 mg/dl and 39.8 ± 6.5 mg/dl, respectively; p< 0.001) than the control group. Compared to the control group, hsCRP levels were higher in the study group (6.39 ± 2.77 mg/L and 2.7 ± 1.43 mg/L, respectively; p< 0.001). Conclusion: There are many risk factors in patients with Leriche syndrome concomitant CAD and severe carotid stenosis. High hsCRP levels, smoking habit, and very low HDL-cholesterol levels come into prominence in these patients. Copyright © 2010 by Türkiye Klinikleri.