Assessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L.

AKKOL E., SÜNTAR İ., ERDOĞAN ORHAN İ., Keles H., Kan A., Çoksari G.

Journal of Cereal Science, vol.53, no.3, pp.285-290, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jcs.2011.01.009
  • Journal Name: Journal of Cereal Science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.285-290
  • Keywords: Antioxidant, Avena sativa, Total phenol and flavonoid, Wound healing
  • Ankara Yıldırım Beyazıt University Affiliated: No


Avena sativa L. (Poaceae) has been reported to have traditional utilization against skin diseases and inflammation. Therefore, in this study, the n-hexane, ethyl acetate, ethanol, and water extracts of A. sativa were investigated for their wound healing and antioxidant activities. Total phenol and flavonoid contents of the extracts were established spectrophotometrically. For the wound healing activity, linear incision and circular excision models on rats and mice were evaluated with a standard ointment Madecassol®. Antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferrous ion-chelating, and ferric-reducing antioxidant power (FRAP) assays. Significant wound healing activity was observed with the ointment formulation of the ethanol extract at 1% concentration. The histopathological examination results also supported the outcome of both linear incision and circular excision wound models. All of the extracts exerted low antioxidant activity in the applied assays. The present study provides a scientific evidence for the traditional usage of A. sativa in the management of wound healing. © 2011.