In vivo phage display in targeted drug delivery applications

Creative Commons License

Karabudak S.

6th International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2025), Ankara, Turkey, 25 - 27 June 2025, pp.1313-1317, (Full Text)

  • Publication Type: Conference Paper / Full Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.1313-1317
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Abstract

In vivo phage display has emerged as a powerful approach for identifying peptides that target specific tissues

or disease states within the body. Unlike traditional in vitro methods, this technique operates under

physiological conditions, allowing peptides to interact with their targets in the complex, dynamic environment

of a living organism. By overcoming biological barriers and recognizing native molecular markers, in vivo

phage display offers a more accurate route to discovering highly specific ligands. This has made it an

increasingly valuable strategy for developing targeted drug delivery systems that minimize off-target effects

while maximizing therapeutic precision. This study explores a range of studies that showcase the diverse

applications of in vivo phage display—from cancer and cardiovascular diseases to infectious diseases, and

mucosal drug delivery. Together, these examples illustrate the method’s remarkable versatility and growing

potential in advancing precision medicine.

Keywords: In vivo phage display, peptide discovery, drug delivery, targeting, biopanning