Effects of catechin consumption on plasma lipid, lipoprotein and lipid peroxidation levels in rats
Fabad Journal of Pharmaceutical Sciences, vol.24, no.4, pp.207-210, 1999 (Scopus)
- Publication Type: Article / Article
- Volume: 24 Issue: 4
- Publication Date: 1999
- Journal Name: Fabad Journal of Pharmaceutical Sciences
- Journal Indexes: Scopus
- Page Numbers: pp.207-210
- Keywords: Catechin, Lipid, Lipid peroxidation, Lipoprotein
- Ankara Yıldırım Beyazıt University Affiliated: No
Abstract
Epidemiological studies indicated that tea consumption reduces the risk of cardiovascular disease. Catechins are abundant in tea and they may account for up to 30% of the dry weight of tea leaves. In this study, the effects of tea catechins on lipid, lipoproteins and lipid peroxidation (LPO) levels were studied in rats. Rats were fed with 1% catechin for three weeks. Thiobarbituric acid reactive substance (TBARS) levels, as the index of lipid peroxidation, were measured by using the colorimeter method in the plasma of animals. Plasma total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and TBARS levels were significantly decreased in catechin fed rats compared to controls. However, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were not significantly affected by catechin treatment. There was a strong positive correlation between plasma LPO and LDL-C or TC in catechin fed rats. These results showed that dietary supplementation of catechin caused decrease of plasma TC, LDLC and LPO levels, and low LPO levels were probably due to the hypolipidemic effect of catechin.