Fabrication of Nanopores in an Ultra-Thin Polyimide Membrane for Biomolecule Sensing

Guzel F. , Avci H.

IEEE Sensors Journal, vol.18, no.7, pp.2641-2646, 2018 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.1109/jsen.2018.2794781
  • Title of Journal : IEEE Sensors Journal
  • Page Numbers: pp.2641-2646


Single molecule detection using nanopores has proven to be a powerful way of identifying biomolecules. There-fore, a variety of materials and methods have been developed by the nanopore community to generate credible outcomes. Here we report as the first time a novel polyimide nanopore platform for single DNA sensing. Novelty of the platform arises both from the ultra-thin structure of the polyimide membrane and also the technique used in the nanopore fabrication on a polymer membrane. Furthermore, the ultra-thin nature of the membrane eliminates the involvement of highly demanding fabrication steps often employed in the solid-state nanopore membrane production. Herein we present the fabrication of nanopores in such an ultrathin polymer membrane and its successful application in sensing DNA molecules at single molecule level, holding a promise as a potential single-molecule analytical device unlike its common use in research.