Coagulopathy parameters in patients with Crimean-Congo hemorrhagic fever and its relation with mortality

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Onguru P., Dagdas S., Bodur H., Yilmaz M., Akinci E., Eren S., ...More

Journal of Clinical Laboratory Analysis, vol.24, no.3, pp.163-166, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1002/jcla.20383
  • Journal Name: Journal of Clinical Laboratory Analysis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.163-166
  • Keywords: Activated protein C resistance, Antithrombin III, Crimean-Congo hemorrhagic fever, Protein C, Protein S
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

Background: Crimean-Congo hemorrhagic fever (CCHF) is an acute illness affecting multiple organ systems and characterized by ecchymosis, visceral bleeding, and hepatic dysfunction. In this study, we aimed to investigate the profile of coagulopathy markers (platelet count, activated partial tromboplastin time (aPTT), prothrombin time (PT), international normalized ratio (INR), fibrinogen, protein C, protein S, antithrombin III, activated protein C resistance (APCR), and D-dimer) and their clinical significance in 83 CCHF-infected patients. Subjects and methods:We studied 83 CCHF patients who were admitted to Ankara Numune Education and Research Hospital during the spring and summer of 2007. We compared the coagulopathy markers of fatal CCHF patients (n = 9) with nonfatal cases (n = 74). Results: Platelet count, PT, aPTT, INR, and fibrinogen were prognostic factors associated with mortality for CCHF. Especially, platelet count<20 × 109 cells/l and aPTT>60 sec were important. Protein C, protein S, APCR, and antithrombin III levels were not associated with mortality. Conclusion: Laboratory tests including classical parameters (platelet count, PT, aPTT, INR, and fibrinogen) of coagulopathy seem to be enough for the followup of CCHF. Protein S, protein C, APCR, and D-dimer levels were not associated with mortality. © 2010 Wiley-Liss, Inc.