Immune thrombocytopenic purpura during maintenance phase of acute lymphoblastic leukemia: A rare coexistence requiring a high degree of suspicion, a case report and review of the literature Akut Lenfoblastik Lösemi İdame Tedavisi Sırasında Gelişen İmmün Trombositopenik Purpura: Fazla Şüphe Gerektiren Nadir Bir Birliktelik, Bir Olgu Sunumu ve Literatür Derlemesi
Turkish Journal of Hematology, vol.32, no.4, pp.363-366, 2015 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 32 Issue: 4
- Publication Date: 2015
- Doi Number: 10.4274/tjh.2014.0138
- Journal Name: Turkish Journal of Hematology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.363-366
- Keywords: Acute lymphoblastic leukemia, Children, Immune thrombocytopenic purpura
- Ankara Yıldırım Beyazıt University Affiliated: No
Abstract
Thrombocytopenia may develop in patients with acute lymphoblastic leukemia (ALL) due to myelosuppression of chemotherapy or relapse. Here we report a pediatric patient with ALL whose platelet counts decreased at the 102nd week of maintenance treatment. Thrombocytopenia was refractory to platelet infusions and bone marrow aspiration revealed remission status for ALL along with increased megakaryocytes. The cessation of chemotherapy for 2 weeks caused no increase in thrombocyte counts. The viral serology was unrevealing. A diagnosis of immune thrombocytopenic purpura (ITP) was established. After administration of intravenous immunoglobulin, the thrombocytopenia resolved. When thrombocytopenia occurs in patients with ALL in remission, ITP should be kept in mind after exclusion of the more common etiologies.