Association of paraoxonase 1 (PON1) L55M and PON1 Q192R gene polymorphisms and risk of psoriasis


KALKAN G., SEÇKİN H. Y. , Benli I., Akbas A., Ates O., Ozyurt H., ...More

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, vol.154, no.3, pp.321-326, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 154 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.23736/s0392-0488.17.05514-6
  • Title of Journal : GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
  • Page Numbers: pp.321-326

Abstract

BACKGROUND: Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. Oxidative stress is considered to be a new etiopathogenetic key factor in the pathogenesis of psoriasis, as a result of the studies performing the association between psoriasis and paraoxonase 1 (PON1) activity. In this study, we aimed to examine the possible associations between the both PON1 L55M and PON1 Q192R polymorphisms and psoriasis susceptibility and disease progression in Turkish population.