Association of paraoxonase 1 (PON1) L55M and PON1 Q192R gene polymorphisms and risk of psoriasis
GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, cilt.154, sa.3, ss.321-326, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 154 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.23736/s0392-0488.17.05514-6
- Dergi Adı: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.321-326
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
BACKGROUND: Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. Oxidative stress is considered to be a new etiopathogenetic key factor in the pathogenesis of psoriasis, as a result of the studies performing the association between psoriasis and paraoxonase 1 (PON1) activity. In this study, we aimed to examine the possible associations between the both PON1 L55M and PON1 Q192R polymorphisms and psoriasis susceptibility and disease progression in Turkish population.