Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

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Uyanıkoğlu A., Sabuncu T., Yıldız R., Cindoğlu Ç., Kirmit A., EREL Ö.

Turkish Journal of Gastroenterology, vol.30, no.10, pp.899-902, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.5152/tjg.2019.18775
  • Journal Name: Turkish Journal of Gastroenterology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.899-902
  • Keywords: Acute pancreatitis, Ischemia-modified albumin, Thiol/disulfide
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP). Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups. Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups. Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.