Intradural langerhans' cell histiocytosis invading skull: Case report and review of the literature Kafatasına İnvazyon Gösteren İntradural Langerhans Hücreli Histiositozis: Vaka Sunumu ve Literatürün Değerlendirilmesi

Kazanci B., Tehli Ö., Kazanci A., Güçlü B.

Journal of Neurological Sciences, vol.31, no.3, pp.609-613, 2014 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2014
  • Journal Name: Journal of Neurological Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.609-613
  • Keywords: Brain tumor, Eosinophilic granuloma, Langerhans' cell histiocytosis, Neuroimaging
  • Ankara Yıldırım Beyazıt University Affiliated: No


© 2014 Ege University Press. All rights reserved.Langerhans' cell histiocytosis (LCH) is a group of idiopathic disorders which are characterized by an abnormal proliferation of histiocytes. Eosinophilic granuloma is an older term for unifocal LCH and it is a slowly progressing disease characterized by an expanding proliferation of Langerhans Cells in various bones most commonly involving the skeletal system. We present a rare case of a solitary LCH originating from dura mater with secondary osseous invasion. A 22-year-old male patient was referred to Neurosurgery Clinic for headache and swelling in the right frontal region. An osteolytic lesion was detected on direct roentgenogram in the right frontal area. Computed tomography (CT) scan showed an osteolytic area involving the inner and outer table. Magnetic resonance imaging (MRI) demonstrated an enhancing mass with a wide dural attachment. Intraoperatively the lesion was found to originate from the dura mater. The lesion was confirmed to be an LCH by immunohistochemical staining. After a 24-month follow-up period, MRI was negative. Intradural development is a possible growth pattern of LCH. Intradural LCH should be kept in mind when evaluating intradural lesions and surgical strategy should be planned accordingly.