EVALUATION OF SERUM THIOL/DISULFIDE HOMEOSTASIS AND ISCHEMIA-MODIFIED ALBUMIN LEVELS IN LUMBAR DISC HERNIATION
Journal of Turkish Spinal Surgery, cilt.32, sa.4, ss.139-143, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/jtss.galenos.2021.66376
- Dergi Adı: Journal of Turkish Spinal Surgery
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.139-143
- Anahtar Kelimeler: IMA, Lumbar disc herniation, thiol-disulfide
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: Lumbar disc herniation (LDH) is a socio-economic burden. The physiopathology of the disease is not clarified completely. This study aimed to investigate the oxidation-reduction balance in LDH via serum thiol-disulfide and ischemia-modified albumin (IMA) levels. Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers. Blood samples were analyzed for total thiol (-SH+ -S-S-), native thiol (-SH), and IMA levels. Disulfide levels and native thiol/total thiol ratio were calculated. The results of the two groups were compared. Results: Native and total thiol levels were significantly higher in the LDH group than in the control group (p=0.007 and p=0.008, respectively). IMA levels were significantly higher in the LDH group than in the control group (p=0.000). The receiver operating characteristic curve demonstrated that the IMA value of 1.41 could predict the LDH with 80% sensitivity and 80% specificity (area under curve=0.888, confidence interval: 0.802-0.974). Conclusion: LDH influences the thiol-disulfide balance and increased IMA levels can predict LDH.