Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats


Yurttutan S., Ozdemir R., Canpolat F. E. , Oncel M. Y. , Uysal B., Unverdi H. G. , ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.183, ss.156-162, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 183 Konu: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jss.2013.01.002
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayıları: ss.156-162

Özet

Background: The pathophysiology of necrotizing enterocolitis (NEC) includes the massive production of endogenous cytokines with exaggerated activation of inflammatory pathways. Colchicine has been used as an anti-inflammatory agent. The aim of this study was to investigate the possible beneficial effects of colchicine in a neonatal rat model of NEC.