Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats


Yurttutan S., Ozdemir R., Canpolat F. E. , Oncel M. Y. , Uysal B., Unverdi H. G. , ...More

JOURNAL OF SURGICAL RESEARCH, vol.183, no.1, pp.156-162, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 183 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2013.01.002
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.156-162

Abstract

Background: The pathophysiology of necrotizing enterocolitis (NEC) includes the massive production of endogenous cytokines with exaggerated activation of inflammatory pathways. Colchicine has been used as an anti-inflammatory agent. The aim of this study was to investigate the possible beneficial effects of colchicine in a neonatal rat model of NEC.