Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats

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Yurttutan S., Ozdemir R., Canpolat F. E., Oncel M. Y., Uysal B., Unverdi H. G., ...More

JOURNAL OF SURGICAL RESEARCH, vol.183, no.1, pp.156-162, 2013 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 183 Issue: 1
• Publication Date: 2013
• Doi Number: 10.1016/j.jss.2013.01.002
• Journal Name: JOURNAL OF SURGICAL RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.156-162
• Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

Background: The pathophysiology of necrotizing enterocolitis (NEC) includes the massive production of endogenous cytokines with exaggerated activation of inflammatory pathways. Colchicine has been used as an anti-inflammatory agent. The aim of this study was to investigate the possible beneficial effects of colchicine in a neonatal rat model of NEC.