The effect of aspartame on the activity of glutathione s transferaze in tissues of brain liver kidney and lung of rats
International Invention Journal of Medicine and Medical Sciences, sa.3, ss.130-135, 2016 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2016
- Dergi Adı: International Invention Journal of Medicine and Medical Sciences
- Sayfa Sayıları: ss.130-135
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
In this study, the changes in GST activities at 12 and 24 h after treatment with aspartame intraperitoneally at the doses of 50, 100 and 200 mg/kg were examined in tissues of liver, lung, kidney and brain of rats. GST activities were found to be significantly higher in liver tissue, whereas there was no significant difference in lung and kidney tissues. In brain tissue, it was found that the inhibition at 12 h after the aspartame dose of 100 mg/kg was statistically significant, but values for the other doses and periods were similar to that of control. Keywords: Glutathione S-transferase, Aspartame, Rat.