Coenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic rats


Ozer E. K. , Goktas M. T. , KILINÇ İ., Pehlivan S., Bariskaner H., UĞURLUOĞLU C., ...More

BIOMEDICINE & PHARMACOTHERAPY, vol.91, pp.912-919, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 91
  • Publication Date: 2017
  • Doi Number: 10.1016/j.biopha.2017.05.017
  • Title of Journal : BIOMEDICINE & PHARMACOTHERAPY
  • Page Numbers: pp.912-919

Abstract

Background: Coenzyme Q10 (CoQ10) is a naturally occurring, lipid-soluble antioxidant and an essential electron carrier in the mitochondrial respiratory chain. In sepsis, CoQ10 deficiency induced by mitochondrial failure can lead to hypoxia, hypoperfusion, oxidative organ damage and finally death. We aimed to investigate the effects of CoQ10 on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis.