Coenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic rats
BIOMEDICINE & PHARMACOTHERAPY, cilt.91, ss.912-919, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 91
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.biopha.2017.05.017
- Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.912-919
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Background: Coenzyme Q10 (CoQ10) is a naturally occurring, lipid-soluble antioxidant and an essential electron carrier in the mitochondrial respiratory chain. In sepsis, CoQ10 deficiency induced by mitochondrial failure can lead to hypoxia, hypoperfusion, oxidative organ damage and finally death. We aimed to investigate the effects of CoQ10 on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis.