An Evaluation of Thiol/Disulphide Homeostasis and HDL Values in Patients with Cholelithiasis: A Prospective Case-control Study

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Ustuner G. Y., AKIN F. E., SAĞLAM S., Gok G., EREL Ö., ERSOY O.

Journal of the College of Physicians and Surgeons Pakistan, cilt.32, sa.4, ss.424-429, 2022 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.29271/jcpsp.2022.04.424
  • Dergi Adı: Journal of the College of Physicians and Surgeons Pakistan
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.424-429
  • Anahtar Kelimeler: Cholelithiasis, Thiol-disulphide homeostasis, Lipid profile, Non-HDL, HDL, Oxidative stress
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet

Özet

© 2022 College of Physicians and Surgeons Pakistan. All rights reserved.Objective: To determine the changes in thiol/disulphide homeostasis in patients determined with asymptomatic cholelithiasis and to investigate any potential correlation between these thiol-disulphide parameters and HDL cholesterol. Study Design: A descriptive, comparative study. Place and Duration of Study: Ankara City Hospital between 15 September and 31 December 2019. Methodology: This study included 42 patients aged 18-70 years, who presented at the Gastroenterology Clinic and were diagnosed with cholelithiasis on ultrasound examination. A control group was formed of 51 healthy volunteers aged 18-70 years. Thiol/disulphide homeostasis and HDL cholesterol was noted and compared between the groups. Results: The mean age was 44.16 ± 13.35 years in cholelithiasis patient group and 31.88±13.27 years in the control group. The triglyceride, VLDL, total cholesterol/HDL, and non-HDL levels were significantly higher and HDL level was significantly low in the patient group (both p <0.05). Regarding thiol-disulphide balance, native thiol, total thiol, and albumin values were found to be statistically significantly low in the patient group (p <0.05), and the IMA, index-1, index-2, and index-3 values were significantly high (p <0.05). Conclusion: The oxidant/antioxidant balance shifted towards oxidation in patients with asymptomatic gallstones. The non-HDL value was increased. There was a positive correlation between the thiol-disulphide parameters and the non-HDL value. The increasing non-HDL amount could be effective in the pathogenesis of gallstone disease by disrupting the oxidative balance.