Pneumatosis cystoides intestinalis: A rare complication after hematopoietic stem cell transplantation

Arman Bilir Ö., Demir A. M. , Akçabelen Y. M. , Ok Bozkaya İ., Gürlek Gökçebay D., Güneş A., ...More

Pediatric Transplantation, vol.25, no.7, 2021 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1111/petr.14136
  • Title of Journal : Pediatric Transplantation
  • Keywords: complication, hematopoietic stem cell transplantation, pediatric, pneumatosis cystoides intestinalis


© 2021 Wiley Periodicals LLCBackground: Pneumatosis cystoides intestinalis (PCI) is a disorder in which widespread air sacs are present in mucosa, submucosa, subserosa, and intraabdominal area of the intestinal wall. It has a heterogeneous clinical presentation as a rare complication of intestinal graft-versus-host disease (GVHD). Computed tomography is the preferred imaging method for the diagnosis. Since the air sacs could be ruptured spontaneously, the presence of free air in the peritoneal cavity does not confirm intestinal perforation. The conservative treatment approach is sufficient in cases that do not require urgent surgical intervention, such as perforation or obstruction. Case: Here, we present a 2.5-year-old patient diagnosed with primary hemophagocytic lymphohistiocytosis (pHLH), who underwent allogeneic hematopoietic stem cell transplantation from a matched unrelated donor (MUD) and developed PCI secondary to intestinal GVHD 14th months after HSCT. Conclusions: Pneumatosis cystoides intestinalis, which is a rare complication, should be kept in mind, especially in patients with intestinal GVHD and receiving intensive immunosuppressive, octreotide, and steroid treatment after HSCT.